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Articles Tagged: Clinical Trial

Brain-computer interface advance allows fast, accurate typing by people with paralysis

Published: February 21, 2017 | Category: News

In a Stanford-led research report, three participants with movement impairment controlled an onscreen cursor simply by imagining their own hand movements.

A clinical research publication led by Stanford University investigators has demonstrated that a brain-to-computer hookup can enable people with paralysis to type via direct brain control at the highest speeds and accuracy levels reported to date. Continue Reading »

UCLA researcher tackles paralysis with electrical stimulation devices

Published: February 10, 2017 | Category: News

A UCLA professor is helping paralyzed individuals regain use of their limbs through electric stimulation of the spinal cord.

In 2015, Reggie Edgerton, the director of the Neuromuscular Research Laboratory at UCLA, developed a robotic exoskeleton that helped a paralyzed man walk. Though the man is still paralyzed and cannot control the exoskeleton’s movement, Edgerton’s lab plans to do more research to make that happen. Continue Reading »

Generating improvement in spinal cord injuries

Published: January 24, 2017 | Category: News

Early clinical trial results announced offer new hope in regenerative medicine

A new therapy to treat spinal cord injuries in people who have lost all motor and sensory function below the injury site shows additional motor function improvement at 6-months and 9-months following treatment with 10 million AST-OPC1. The positive efficacy results from an ongoing research study were announced on Jan. 24 in a conference held by Asterias Biotherapeutics, Inc., the biotechnology company that manufactures AST-OPC1. Continue Reading »

New trial may revolutionize treatment of spinal cord injury patients

Published: January 20, 2017 | Category: News

Queensland researchers are launching a world-first clinical trial aimed at improving recovery from spinal cord injuries.

In the study, led by The University of Queensland and The Princess Alexandra (PA) Hospital, a new anti-inflammatory drug will be given to participants within hours of spinal trauma in an effort to minimize tissue damage.

Dr Marc Ruitenberg from the UQ School of Biomedical Sciences said when the spinal cord is injured, it becomes inflamed and this causes a lot of additional damage. Continue Reading »

What are stem cells and how will they be used to treat the world’s most debilitating diseases?

Published: January 12, 2017 | Category: Answers

Stem cell research is often controversial but it has also led to incredible medical progress in recent years.

Stem cell research is at defining moment. Although it can be controversial and does raise a lot of important ethical issues, this area of medical science has been characterised by a number of important advances, ever since the first embryonic stem cells were isolated from mice in the 1980s. In the near future, it could reshape the way we treat some of the world’s most debilitating diseases.

Stem cells have already been used as treatment for a number of years – think bone marrow transplant – and they have the potential to help with many other medical conditions. Continue Reading »

Soon-to-be doctor behind new spinal cord research six years after becoming quadriplegic

Published: November 5, 2016 | Category: News | Spinal Cord Injury:

dinesh-palipana-quadriplegicMOST doctors study for years so they can help others but for Southport’s Dinesh Palipana, it is much more ­personal.

A month out from his graduation ceremony at Griffith University, the 32-year-old doesn’t just want to help others, he also wants to help himself.

“I’ve had a vested interest and a passion to cure spinal cord injury and cure myself in the process,” he said.

Part-way through his medical degree in 2010, Mr Palipana was driving home to the Gold Coast from visiting his parents in Brisbane when his car aquaplaned on a wet road and overturned near the Gateway Bridge. Continue Reading »

Human Neuron Transplants Treat Spinal Cord Injury in Mice

Published: September 22, 2016 | Category: News

mge_spheroidsChronic pain and loss of bladder control are among the most devastating consequences of spinal cord injury, rated by many patients as a higher priority for treatment than paralysis or numbness. Now a UC San Francisco team has transplanted immature human neurons into mice with spinal cord injuries, and shown that the cells successfully wire up with the damaged spinal cord to improve bladder control and reduce pain. This is a key step towards developing cell therapies for spinal cord injury in humans, say the researchers, who are currently working to develop the technique for future clinical trials. Continue Reading »

Paralyzed Man Regains Use of Arms and Hands After Experimental Stem Cell Therapy at Keck Hospital of USC

Published: September 7, 2016 | Category: News | Spinal Cord Injury:

neurosurgery-stem-cell-spine-patient-kris-boesenInitial Results Offer Hope for Patients to Reclaim Independence After Suffering Severe Spinal Injury

LOS ANGELES, Sept. 7, 2016 /PRNewswire/ — Keck Medical Center of USC today announced that a team of doctors became the first in California to inject an experimental treatment made from stem cells, AST-OPC1, into the damaged cervical spine of a recently paralyzed 21-year-old man as part of a multi-center clinical trial. Continue Reading »

Stem Cell Agency Spinal Cord Injury Clinical Trial Passes Safety Hurdles

Published: August 31, 2016 | Category: News | Spinal Cord Injury: , ,

logo-CIRMOakland, CA – A clinical trial using stem cells to treat people with recent spinal cord injuries has cleared two key safety hurdles, and been given approval to expand the therapy to a larger group of patients with a much higher dose of cells.

Asterias Biotherapeutics announced that its Data Monitoring Committee (DMC) has reviewed the safety data from the first two groups of patients treated and found no problems or adverse side effects. One group of three patients was given 2 million cells. The second group of five patients received 10 million cells. Asterias is now cleared to enroll another 5-8 patients with 20 million cells. Continue Reading »

Monitoring upper-limb recovery after cervical spinal cord injury: insights beyond assessment scores.

Published: August 18, 2016 | Category: Information

Background: Pre-clinical investigations in animal models demonstrate that enhanced upper-limb (UL) activity during rehabilitation promotes motor recovery following spinal cord injury (SCI). Despite this, following SCI in humans, no commonly applied training protocols exist and therefore activity-based rehabilitative therapies (ABRT) vary in frequency, duration and intensity. Quantification of UL recovery is limited to subjective questionnaires or scattered measures of muscle function and movement tasks. Continue Reading »