Thursday, May 28th 2015

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Articles Tagged: Clinical Trial

India to participate in first clinical study trial to treat spinal cord injury using stem cells

Published: May 11, 2015 | Category: News

392-320x240By involving 18 patients, India will soon become a part of a first-of-its-kind clinical trial, a collaborative study conducted in China, Norway and America, involving 240 patients for treating spinal cord injury in humans through stem-cells.

India will be a part of a first-of-its-kind clinical trial, for treating spinal cord injury in humans through stem-cells. India will a part of the collaborative study conducted in China, Norway and America involving 240 patients led by China-based stem cell researcher Dr Wise Young. Continue Reading »

Asterias begins enrollment for AST-OPC1 Phase 1/2a trial to treat complete cervical spinal cord injury

Published: March 5, 2015 | Category: News

ast_opc1Asterias Biotherapeutics, Inc. (NYSE MKT: AST), a leading biotechnology company in the emerging field of regenerative medicine, announced today that Atlanta-based Shepherd Center, one of the nation’s top rehabilitation hospitals for spinal cord injury and brain injury, has commenced enrollment for the Phase 1/2a clinical trial of AST-OPC1 (oligodendrocyte progenitor cells) in newly injured patients with sensory and motor complete cervical spinal cord injury (SCI).

The Phase 1/2a trial follows the successful completion of the Phase 1 trial of AST-OPC1, which met its primary endpoints of safety and feasibility when administered to five patients with neurologically complete, thoracic SCI. Continue Reading »

Stem cells from human embryos prove safe, improve vision -study

Published: October 14, 2014 | Category: News

(Reuters) – The longest-running trial of stem cells derived from a human embryo found that the cells caused patients none of the problems scientists feared, such as forming tumors, and reversed partial blindness in about half the eyes receiving transplants, researchers reported on Tuesday. Continue Reading »

ISU clinical trial hopes to aid paralyzed dogs

Published: October 11, 2014 | Category: News

DaisyVeterinarians at Iowa State University are hoping to give 60 dogs a second chance at walking.

The university’s clinical trial for paralyzed dogs is testing a new drug that could potentially help more dogs overcome severe spinal cord injuries.

The trial is run by Dr. Nick Jeffery and Dr. Hilary Hu with ISU’s Veterinary Medical Center, and the team began recruiting for their trial in January. The trial will be using the test drug chondroitinase, an enzyme which helps to dissolve scar tissue around the dog’s injury. Continue Reading »

StemCells Inc. Initiates Phase 2 Clinical Trial In Cervical Spinal Cord Injury

Published: October 7, 2014 | Category: News

stemcellsinc-logoNEWARK, Calif., Oct. 7, 2014 (GLOBE NEWSWIRE) — StemCells, Inc. (Nasdaq:STEM), a world leader in the research and development of cell based therapies for the treatment of disorders of the central nervous system, announced today that it has initiated its Pathway® Study, a Phase II proof of concept clinical trial using its proprietary HuCNS-SC® platform of human neural stem cells for the treatment of cervical spinal cord injury (SCI). Approximately 1.3 million people in the United States report being paralyzed due to an SCI, and there currently are no effective treatments available. Approximately 56% of the spinal cord injuries occur in the cervical region. Overall, approximately 13% of SCI patients have no mobility and 35% have limited mobility after the traumatic injury. Continue Reading »

Clinical trial will target spinal-cord injuries

Published: September 15, 2014 | Category: News

health-newsThe University of Arizona Medical Center is the site of a two-year clinical trial for a drug that could help people with acute spinal-cord injuries.

Sixty trauma centers in the U.S., Canada and Europe will test the safety and efficacy of the investigational drug SUN13837, to determine whether it can protect and regenerate spinal nerves, UA Medical Center officials say.

The study is sponsored by Asubio Pharmaceuticals, Inc. Patients will be randomly assigned to receive either a placebo or SUN13837 within 12 hours of injury and then daily for 28 days. Continue Reading »

Experimental Drug Being Tested at Shepherd Center May Improve Mobility after Spinal Cord Injury

Published: August 25, 2014 | Category: News

800_spineandbodyillustration-shepherdcenter-horizontalOnly hours after a traumatic spinal cord injury, when the life-and-death moments have passed and ongoing challenges are just coming into focus, some patients are receiving an experimental drug that may change their lives.

The investigational medication, called SUN13837, is given intravenously within 12 hours of a traumatic spinal cord injury (SCI) and then daily for 28 days. It is a fat-soluble molecule that may protect damaged neurons and even promote new nerve growth, preventing some loss of function. Continue Reading »

New Methods Show Promise for Rehabilitating Paralyzed Patients With Spinal Cord Injury

Published: June 23, 2014 | Category: News

new-methods-show-promise-rehabilitating-paralyzed-patients-spinal-cord-injuryAn array of techniques – some available now and others on the horizon – aim to restore movement and other functions in patients with spinal cord injuries.

A paraplegic wearing an Iron Man-like exoskeleton took the first kick of the World Cup soccer tournament during the opening ceremony in Sao Paulo, Brazil, a testament to recent advances in treating spinal cord injuries.

The robotic bodysuit took cues from the user’s brain activity to power his steps forward. It was developed by Brazilian doctor Miguel Nicolelis, who is on the faculty at Duke University, and more than 150 scientists from around the world. Continue Reading »

Stem Cell Trials to Treat Spinal Cord Injuries

Published: June 5, 2014 | Category: Information

Neuron-with-oligodendrocyte-and-myelin-sheathWhile human embryonic stem cells (hESCs) were originally created in 1998, it wasn’t until 2009 — over a decade later — that they were approved by the FDA for use in a clinical trial in people. It was a long wait, but the trial was quite the promising one. The clinical trial, undertaken by the Geron Corporation, was for using hESCs to treat patients with spinal cord injuries and paralysis.

Very unfortunately, the trial became stalled in late 2011, mostly due to financial concerns (but it did undoubtedly help pave the way for other hESC-based clinical trials to get FDA approval starting in 2010). Continue Reading »

InVivo Therapeutics Initiates First Clinical Trial of Neuro-Spinal Scaffold

Published: April 28, 2014 | Category: News

InVivo TherapeuticsScaffold Designed to Facilitate Neural Growth in Spinal Cord Injury

CAMBRIDGE, Mass.–(BUSINESS WIRE)–April 28, 2014– InVivo Therapeutics Holdings Corp. (NVIV) announced today that it has begun shipment of its innovative investigational device, a degradable polymer Neuro-Spinal Scaffold for spinal cord injury (SCI) patients, for initiation of the company’s first clinical trial. InVivo has pioneered a new treatment platform utilizing a biocompatible polymer-based device that is intended to promote structural support for spinal cord regeneration while improving functional recovery and prognosis after a traumatic SCI. In preclinical studies, the Neuro-Spinal Scaffold promoted cell adhesion, neurite sprouting, the growth of remodeled spinal cord tissue containing myelinated axons, and improved motor function. Continue Reading »