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Articles Tagged: Clinical Trial

Stem cell treatment could help paralyzed patients move

Published: January 15, 2016 | Category: News | Spinal Cord Injury:

Louis TontodonatoLouis Tontodonato’s hopes and dreams may well lie in a virtual coin flip, a digital roll of the dice.

Paralyzed from the neck down, the 20-year-old Naples, Fla., man has enrolled in the first clinical trial testing the ability of stem cells to repair spinal cord injuries and restore sensation and movement in quadriplegics. Early studies in animals and humans have had remarkable results, enabling patients to resume everyday tasks they thought had been lost forever. If those early effects are validated, the treatment has the potential to drastically improve the quality of life and independence of thousands of spinal cord injury patients. Continue Reading »

The Year in Review: SCI Research Breakthroughs in 2015

Published: December 21, 2015 | Category: Information

spinal cord injury year-in-reviewAs we cross the threshold into 2016, we are one step closer to our goal of finding a cure for paralysis.

Moving full speed ahead towards that goal, Conquer Paralysis Now compiled a brief retrospective. 2015 has been an incredible year for spinal cord injury research, with breakthroughs in a variety of potential treatments, on top of important strides made by individuals with SCI. Take a look at some key milestones from this past year and stay tuned for what’s to come in 2016. Happy New Year! Continue Reading »

Motor Improvement Seen in Patients with Cervical Spinal Cord Injury After Stem Cell Implantation

Published: December 16, 2015 | Category: News

Allan-Levi-MDAfter six months, the patients in the StemCells, Inc. trial being conducted at University of Miami Hospital are demonstrating improvements in both strength and function. They are the first cohort in the Phase II pathway study, led by Allan D. Levi, M.D., Ph.D., professor and Chair of the Department of Neurological Surgery and The Miami Project to Cure Paralysis, which is measuring the effects of implanting stem cells in patients with cervical spinal cord injury (SCI). The assessment of motor function involved using tests of dexterity and grip.

Levi, who is also Chief of Neurosurgery at Jackson Memorial Hospital, was the first investigator to perform a stem cell transplant into the chronically injured cervical spinal cord of a patient. Continue Reading »

Stem cell research for spinal cord injury

Published: December 10, 2015 | Category: Information

Spinal cord injury (SCI) involves damage to the area that can cause an impairment of loss of muscle control, movement and sensation.  Currently, patients with injury to the spinal cord are managed with physical therapy, occupation therapy and other rehabilitation methods to cope with the physical changes.

However, stem cell research may present a new approach to the management of this patient group, allowing for a potential improvement in the symptoms of the condition, such as incontinence, muscular control and sexual function. Continue Reading »

A shattering crash, an online chronicle, and an unexpected twist

Published: August 21, 2015 | Category: News | Spinal Cord Injury:

Jesi Stracham with her dogIn the age of social media, patients who test experimental treatments wield surprising clout.

The tweets and the selfies, the uploaded video clips, felt like a natural way for Jesi Stracham to record her halting progress as she fought to recover from a motorcycle accident that had left her paralyzed from the chest down.

She had no idea, as she tapped away at her iPhone from her hospital bed, what her bubbly posts would unleash. Continue Reading »

Regenerating nerve tissue in spinal cord injuries

Published: August 13, 2015 | Category: News

Rush-University-Medical-CenterRush begins participation in novel study using stem cells to treat spinal cord injuries

Researchers at Rush University Medical Center are exploring a new therapy using stem cells to treat spinal cord injuries within the first 14 to 30 days of injury. Rush is only the second center in the country currently studying this new approach.

The therapy uses a population of cells derived from human embryonic stem cells containing progenitor cells that support nerve cells and can potentially make poorly functioning nerves function better. Continue Reading »

Olfactory cells transplanted to treat spinal cord injury

Published: June 19, 2015 | Category: News

Three years after they treated patients with spinal cord injury in a randomized clinical trial with transplanted cells from the patients’ olfactory mucosa (nasal cavities) to build a ‘bridge’ to span the gap between the damaged ends of the spinal cord, researchers found that some recipients had experienced a range of modest improvements and determined that the use of olfactory mucosa lamina propria (OLP) transplants was ‘promising and safe.’ Continue Reading »

‘Exciting’ progress for spinal injury drug

Published: June 12, 2015 | Category: News

Anthony FaingaaPioneers in the field of neurological therapy want paramedics to be armed with a breakthrough drug to quickly stop the damage spreading.

It’s the latest stage in the development of a project which started in 2011 at the University of Auckland.

The potential to carry the drug in the back of ambulances follows trials on rodents. Those tests confirmed a dose of peptide medicine could be administered into people’s veins, instead of straight to the spinal cord. Continue Reading »

India to participate in first clinical study trial to treat spinal cord injury using stem cells

Published: May 11, 2015 | Category: News

392-320x240By involving 18 patients, India will soon become a part of a first-of-its-kind clinical trial, a collaborative study conducted in China, Norway and America, involving 240 patients for treating spinal cord injury in humans through stem-cells.

India will be a part of a first-of-its-kind clinical trial, for treating spinal cord injury in humans through stem-cells. India will a part of the collaborative study conducted in China, Norway and America involving 240 patients led by China-based stem cell researcher Dr Wise Young. Continue Reading »

Asterias begins enrollment for AST-OPC1 Phase 1/2a trial to treat complete cervical spinal cord injury

Published: March 5, 2015 | Category: News

ast_opc1Asterias Biotherapeutics, Inc. (NYSE MKT: AST), a leading biotechnology company in the emerging field of regenerative medicine, announced today that Atlanta-based Shepherd Center, one of the nation’s top rehabilitation hospitals for spinal cord injury and brain injury, has commenced enrollment for the Phase 1/2a clinical trial of AST-OPC1 (oligodendrocyte progenitor cells) in newly injured patients with sensory and motor complete cervical spinal cord injury (SCI).

The Phase 1/2a trial follows the successful completion of the Phase 1 trial of AST-OPC1, which met its primary endpoints of safety and feasibility when administered to five patients with neurologically complete, thoracic SCI. Continue Reading »