Articles Tagged: Clinical Trial
March 22, 2016 | Category: News
A paralyzing injury to the neck during recreational activities such as horseback riding or playing football usually has permanent, lifelong effects that change a person’s life dramatically. With no options for the repair of spinal cord injuries, many are left with little hope for recovery.
Now researchers at Rush are exploring a new therapy that uses stem cells to treat spinal cord injuries within the first 14 to 30 days of injury. Rush is one of only two centers in the country currently studying this new approach. Continue Reading »
Following spinal cord injury, most patients experience an exaggeration of muscle tone called spasticity, which frequently leads to physical disability.
A team at the Institut de Neurosciences de la Timone (CNRS/Aix-Marseille Université) has just identified one of the molecular mechanisms responsible for this phenomenon. It has also proposed two therapeutic solutions that have proved conclusive in animals, one of which will be tested during phase II clinical trials as early as this year. This work, published in Nature Medicineon 14 March 2016, thus opens new therapeutic avenues to reduce this physical disability.
Twelve million people throughout the world suffer from a motor disorder called spasticity. Continue Reading »
March 13, 2016 | Category: News
Researchers are currently evaluating the potential of stem cell transplantation as a treatment for many neurological disorders, including spinal cord injury (SCI). Stem cells are unique from other cells in the body:
- Stem cells can self-renew (make copies of themselves)
- Stem cells can respond to signals within the body and become specialized (this is known as differentiation)
Studying stem cell transplantation for SCI may help us learn if stem cells can help either replace or repair spinal cord cells that were damaged by injury which may in turn improve spinal cord function. Continue Reading »
February 26, 2016 | Category: News
| Spinal Cord Injury: C-4
Three years ago, Michael Fraser broke his neck in a diving accident near his Vandergrift home but remembers little about it.
But in April, the man with quadriplegia underwent an experimental neural stem-cell procedure that wasn’t only a life-changing experience but could represent the first interventional treatment for spinal cord injuries.
Mr. Fraser, 24, now can lift himself from his wheelchair into bed without assistance. He breathes more freely and deeply and has greater core strength with better dexterity. Previously he could manage only a half-mile on his arm-powered elliptical but now does two to three miles, he said. Continue Reading »
Louis Tontodonato’s hopes and dreams may well lie in a virtual coin flip, a digital roll of the dice.
Paralyzed from the neck down, the 20-year-old Naples, Fla., man has enrolled in the first clinical trial testing the ability of stem cells to repair spinal cord injuries and restore sensation and movement in quadriplegics. Early studies in animals and humans have had remarkable results, enabling patients to resume everyday tasks they thought had been lost forever. If those early effects are validated, the treatment has the potential to drastically improve the quality of life and independence of thousands of spinal cord injury patients. Continue Reading »
As we cross the threshold into 2016, we are one step closer to our goal of finding a cure for paralysis.
Moving full speed ahead towards that goal, Conquer Paralysis Now compiled a brief retrospective. 2015 has been an incredible year for spinal cord injury research, with breakthroughs in a variety of potential treatments, on top of important strides made by individuals with SCI. Take a look at some key milestones from this past year and stay tuned for what’s to come in 2016. Happy New Year! Continue Reading »
December 16, 2015 | Category: News
After six months, the patients in the StemCells, Inc. trial being conducted at University of Miami Hospital are demonstrating improvements in both strength and function. They are the first cohort in the Phase II pathway study, led by Allan D. Levi, M.D., Ph.D., professor and Chair of the Department of Neurological Surgery and The Miami Project to Cure Paralysis, which is measuring the effects of implanting stem cells in patients with cervical spinal cord injury (SCI). The assessment of motor function involved using tests of dexterity and grip.
Levi, who is also Chief of Neurosurgery at Jackson Memorial Hospital, was the first investigator to perform a stem cell transplant into the chronically injured cervical spinal cord of a patient. Continue Reading »
Spinal cord injury (SCI) involves damage to the area that can cause an impairment of loss of muscle control, movement and sensation. Currently, patients with injury to the spinal cord are managed with physical therapy, occupation therapy and other rehabilitation methods to cope with the physical changes.
However, stem cell research may present a new approach to the management of this patient group, allowing for a potential improvement in the symptoms of the condition, such as incontinence, muscular control and sexual function. Continue Reading »
August 21, 2015 | Category: News
| Spinal Cord Injury: Paraplegia
In the age of social media, patients who test experimental treatments wield surprising clout.
The tweets and the selfies, the uploaded video clips, felt like a natural way for Jesi Stracham to record her halting progress as she fought to recover from a motorcycle accident that had left her paralyzed from the chest down.
She had no idea, as she tapped away at her iPhone from her hospital bed, what her bubbly posts would unleash. Continue Reading »
August 13, 2015 | Category: News
Rush begins participation in novel study using stem cells to treat spinal cord injuries
Researchers at Rush University Medical Center are exploring a new therapy using stem cells to treat spinal cord injuries within the first 14 to 30 days of injury. Rush is only the second center in the country currently studying this new approach.
The therapy uses a population of cells derived from human embryonic stem cells containing progenitor cells that support nerve cells and can potentially make poorly functioning nerves function better. Continue Reading »