Articles Tagged: Neurons
Finding a solution for brain and spinal cord injury
The Fournier lab at the Montreal Neurological Institute is working to answer a fundamental question: what happens after a nerve cell gets injured? Damage to nerve cells in the central nervous system (CNS), which consists of the brain and the spinal cord, often means permanent damage due to these cells’ limited capacity to repair and regenerate.
Unlike many other cells in the human body, adult nerve cells in the CNS cannot spontaneously repair. Hence, damage to the spinal cord can result in permanent paralysis to the body parts below the site of injury. Continue Reading »
July 16, 2012 | Category: News
Protocol may open new avenues for cell-replacement therapies for neurological conditions
LA JOLLA, CA—For more than 20 years, doctors have been using cells from blood that remains in the placenta and umbilical cord after childbirth to treat a variety of illnesses, from cancer and immune disorders to blood and metabolic diseases.
Now, scientists at the Salk Institute for Biological Studies have found a new way-using a single protein, known as a transcription factor-to convert cord blood (CB) cells into neuron-like cells that may prove valuable for the treatment of a wide range of neurological conditions, including stroke, traumatic brain injury and spinal cord injury. Continue Reading »
January 30, 2011 | Category: News
Among stem cell biologists there are few better-known proteins than nestin, whose very presence in an immature cell identifies it as a “stem cell,” such as a neural stem cell. As helpful as this is to researchers, until now no one knew which purpose nestin serves in a cell.
In a study published in the Jan. 30, 2011, advance online edition of Nature Neuroscience, Salk Institute of Biological Studies investigators led by Kuo-Fen Lee, PhD., show that nestin has reason for being in a completely different cell type–muscle tissue. There, it regulates formation of the so-called neuromuscular junction, the contact point between muscle cells and “their” motor neurons. Continue Reading »
December 3, 2010 | Category: News
Electronic “bridge” could one day assist paralysis patients.
Until recently, severe spinal cord injuries came with a fairly definite diagnosis of paralysis, whether partial or complete. But new developments in both stem-cell therapy and electronic stimulation have begun to provide hope, however distant, that paralysis may not be a life sentence. Complicated muscle stimulation devices can enable limited standing and walking, and the first embryonic stem-cell trials began last year. Other techniques, however, may provide an even simpler solution. Continue Reading »
November 16, 2010 | Category: News
Newswise — The spleen, an organ that helps the body fight infections, might also be a source of the cells that end up doing more harm than good at the site of a spinal cord injury, new research suggests.
Considering the spleen’s role in the after-effects of spinal cord injury could change the way researchers pursue potential treatments for these devastating injuries. Continue Reading »
November 15, 2010 | Category: News
(Reuters) – StemCells Inc has filed for Swiss regulatory approval for the first clinical trial of its nerve stem cells in patients with spinal cord injuries as much as a year old, the company said.
It expects to enroll about a dozen patients whose injuries are between three and 12 months old.
“To date, the focus has been on the acute spinal cord injury phase,” StemCells CEO Martin McGlynn said in a telephone interview. “That’s an important area to address, but the largest unmet need is those who have passed that immediate acute phase of injury.” Continue Reading »
November 14, 2010 | Category: News
Newswise — A study led by researchers in the Department of Neurosciences at the University of California, San Diego School of Medicine shows unexpected and extensive natural recovery after spinal cord injury in primates. The findings, to be published November 14 in the advance online edition of Nature Neuroscience, may one day lead to the development of new treatments for patients with spinal cord injuries.
While regeneration after severe brain and spinal cord injury is limited, milder injuries are often followed by good functional recovery. Continue Reading »
November 5, 2010 | Category: News
Millions of people worldwide experience spinal cord injuries. Breakthroughs bring researchers progress, but a complete cure is a long way off
Spinal cord repair focuses on finding ways to make axons regrow and connect properly, replace damaged neurons, protect surviving neurons from further injury and retrain neural circuits to repair body functions. Continue Reading »
October 11, 2010 | Category: News
Oct. 11 (Bloomberg) — Geron Corp. used a therapy made from stem cells taken from human embryos to treat a patient paralyzed by a spinal-cord injury in the first U.S.-authorized test of the technology.
The patient was treated Oct. 8 at Shepherd Center, a rehabilitation hospital in Atlanta, the company said today in a statement. The study is designed to test the safety of Geron’s therapy in patients with spinal cord injuries. The U.S. Food and Drug Administration gave permission in July for Geron to start the study after a halt of almost a year over safety concerns. Continue Reading »
October 10, 2010 | Category: News
Imagine the plight of a young person, the sole bread-earner in the family, getting paralysed below the neck as a result of a road accident, with no movement or sensation in all four limbs and no control over his bowel and bladder. This poses a big physical, psychological and economic challenge not only for the individual but also for the whole family. Continue Reading »