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Articles Tagged: Stem Cells

Asterias Biotherapeutics Receives FDA Clearance to Enroll C-4 Patients in SCiStar Study

Published: July 10, 2017 | Category: News | Spinal Cord Injury:

Ability to enroll patients with second most common cervical spinal cord injury broadens eligible population for SCiStar study and future trials

FREMONT, Calif., July 10, 2017 /PRNewswire/ — Asterias Biotherapeutics, Inc. (NYSE MKT: AST), a biotechnology company pioneering the field of regenerative medicine, today announced that the U.S. Food and Drug Administration (FDA) has accepted the company’s amendment to the clinical research protocol for its ongoing AST-OPC1 SCiStar Phase 1/2a clinical trial in motor complete cervical spinal cord injury (SCI). The amendment expands the eligibility criteria to include patients with a C-4 spinal cord injury and extends the dosing window from 14 to 30 days to 21 to 42 days post-injury. Continue Reading »

Lab-Grown Neurons Could Help Heal Spinal Injuries and Restore Movement

Published: April 26, 2017 | Category: Featured News Videos

Researchers grew human spinal cord neurons from stem cells and injected them into healthy mice, where they successfully connected with other neurons. Continue Reading »

The future of stem cells: tackling hype versus hope

Published: January 28, 2017 | Category: News

Professor Alan Mackay-SimControversy surrounds the link between Australian of the Year Alan Mackay Sim’s research and a Polish team who restored mobility for a paraplegic man.

For many people suffering from disabling conditions, such as Parkinson’s disease, spinal injury and paralysis, multiple sclerosis, macular degeneration, heart disease, renal failure and even cancer, announcements in the press around breakthroughs in stem cell research undoubtedly bring hope.

The challenge remains how to accurately communicate what is genuinely possible in terms of therapies and what we scientists hope might be possible but do not yet have strong evidence for. Continue Reading »

Generating improvement in spinal cord injuries

Published: January 24, 2017 | Category: News

Early clinical trial results announced offer new hope in regenerative medicine

A new therapy to treat spinal cord injuries in people who have lost all motor and sensory function below the injury site shows additional motor function improvement at 6-months and 9-months following treatment with 10 million AST-OPC1. The positive efficacy results from an ongoing research study were announced on Jan. 24 in a conference held by Asterias Biotherapeutics, Inc., the biotechnology company that manufactures AST-OPC1. Continue Reading »

What are stem cells and how will they be used to treat the world’s most debilitating diseases?

Published: January 12, 2017 | Category: Answers

Stem cell research is often controversial but it has also led to incredible medical progress in recent years.

Stem cell research is at defining moment. Although it can be controversial and does raise a lot of important ethical issues, this area of medical science has been characterised by a number of important advances, ever since the first embryonic stem cells were isolated from mice in the 1980s. In the near future, it could reshape the way we treat some of the world’s most debilitating diseases.

Stem cells have already been used as treatment for a number of years – think bone marrow transplant – and they have the potential to help with many other medical conditions. Continue Reading »

Human Neuron Transplants Treat Spinal Cord Injury in Mice

Published: September 22, 2016 | Category: News

mge_spheroidsChronic pain and loss of bladder control are among the most devastating consequences of spinal cord injury, rated by many patients as a higher priority for treatment than paralysis or numbness. Now a UC San Francisco team has transplanted immature human neurons into mice with spinal cord injuries, and shown that the cells successfully wire up with the damaged spinal cord to improve bladder control and reduce pain. This is a key step towards developing cell therapies for spinal cord injury in humans, say the researchers, who are currently working to develop the technique for future clinical trials. Continue Reading »

Asterias stem cell therapy shows promise in spinal cord paralysis: U.S. study

Published: September 14, 2016 | Category: News

asterias-biotherapeuticsAn experimental stem cell therapy developed by Asterias Biotherapeutics restored some movement to patients paralyzed by recent spinal cord injuries, according to interim data from a small study being presented on Wednesday.

One of the five patients in the trial regained use of both arms and hands, and is now able to feed himself, send texts on a phone and operate a wheelchair, the Fremont, California-based company said.

Three months after the cells were implanted, the study met its efficacy goal of two patients regaining return of two motor levels of functioning on at least one side of their body, the company said.

All five people in the study have experienced some upper extremity improvement so far, Asterias said. Continue Reading »

Paralyzed Man Regains Use of Arms and Hands After Experimental Stem Cell Therapy at Keck Hospital of USC

Published: September 7, 2016 | Category: News | Spinal Cord Injury:

neurosurgery-stem-cell-spine-patient-kris-boesenInitial Results Offer Hope for Patients to Reclaim Independence After Suffering Severe Spinal Injury

LOS ANGELES, Sept. 7, 2016 /PRNewswire/ — Keck Medical Center of USC today announced that a team of doctors became the first in California to inject an experimental treatment made from stem cells, AST-OPC1, into the damaged cervical spine of a recently paralyzed 21-year-old man as part of a multi-center clinical trial. Continue Reading »

Study says stem cell treatment can aid recovery of spinal injuries

Published: August 23, 2016 | Category: News

stem-cellStem Cell treatment or the Human Embryonic Stem Cells (HESC) is effective in the replacement of damaged neurons, re-establishment of lost axonal connections, and providing of neuro-protective factors to allow the healing and recovery of spinal cord injury, revealed a study.

Stem Cell treatment or the Human Embryonic Stem Cells (HESC) is effective in the replacement of damaged neurons, re-establishment of lost axonal connections, and providing of neuro-protective factors to allow the healing and recovery of spinal cord injury, revealed a study. Continue Reading »

StemCells Ends Clinical Trial for Spinal Cord Injury due to Financial Constraints

Published: June 1, 2016 | Category: News

stemcellsinc-logoStemCells Inc., a California-based biotech company announced that they will stop developing the potential treatment for spinal cord injury after a failed mid-stage clinical trial. The company stock went down to $3.03 per share at the start of the pre-market trade.  StemCells reported that they still have $5.5 million in cash as of May 31, but they don’t have a liquidating distribution to their stockholders.

The company said that the amount that they can give to the shareholders depends on the liquid assets, any liabilities, and costs of the wind down. Continue Reading »