Tuesday, July 15th 2014

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Articles Tagged: Stem Cells

Stem-cell advances may quell ethics debate

Published: June 22, 2014 | Category: Featured News

Robert WaddellRobert Waddell says he’s glad the stem cells that healed him came from “a guy who was 50 years old” and not a human embryo.

As a Catholic, Waddell opposes the destruction of embryos and didn’t want to rely on embryonic stem cells to cure his kidney disease. But he avoided this moral dilemma by getting bone marrow stem cells from a friend who donated a kidney as part of a University of Louisville study.

“It has nothing to do with embryonic stem cells,” said Waddell, a 47-year-old father of four. “That made it a lot easier.” Continue Reading »

Stem Cells Fast Facts

Published: June 20, 2014 | Category: Information

(CNN) — Here’s a look at what you need to know about stem cells.

Scientists believe that stem cell research can be used to treat medical conditions including Parkinson’s Disease, spinal cord injury, stroke, burns, heart disease, diabetes, osteoarthritis, and rheumatoid arthritis. Continue Reading »

Stem Cell Trials to Treat Spinal Cord Injuries

Published: June 5, 2014 | Category: Information

Neuron-with-oligodendrocyte-and-myelin-sheathWhile human embryonic stem cells (hESCs) were originally created in 1998, it wasn’t until 2009 — over a decade later — that they were approved by the FDA for use in a clinical trial in people. It was a long wait, but the trial was quite the promising one. The clinical trial, undertaken by the Geron Corporation, was for using hESCs to treat patients with spinal cord injuries and paralysis.

Very unfortunately, the trial became stalled in late 2011, mostly due to financial concerns (but it did undoubtedly help pave the way for other hESC-based clinical trials to get FDA approval starting in 2010). Continue Reading »

Neuralstem spinal cord injury stem cell trial approved to commence at University Of California

Published: April 18, 2014 | Category: News | Spinal Cord Injury: ,

Neuralstem LogoNeuralstem, announced that the Institutional Review Board of the University of California, San Diego, School of Medicine has approved the phase I safety trial to treat chronic spinal cord injury (cSCI) with its NSI-566 stem cells. The NSI-566/cSCI phase I trial will enroll patients with thoracic spinal cord injuries (T2-T12) who have an American Spinal Injury Association (AIS) A level of impairment, between one and two years after injury. AIS A impairment, which is complete paralysis, refers to a patient with no motor or sensory function in the relevant segments at and below the injury. Continue Reading »

Light-Activated Neurons May Restore Function to Paralyzed Muscles

Published: April 10, 2014 | Category: News

Light-Activated Neurons Restore FunctionLONDON, April 10, 2014 — Paralysis caused by a motor neuron disease or spinal cord injury understandably causes feelings of hopelessness, helplessness and despair. But there is optimism in a new technique that can artificially control paralyzed muscles using light.

The technique, developed at University College London and King’s College London could potentially restore the function of muscles afflicted by motor neuron disease or spinal cord injury. Continue Reading »

First Study Tracking Stem Cell Treatments For Children With Spinal Cord Injuries Shows Potential Benefit

Published: February 3, 2014 | Category: News

STEM CELLS Translational MedicinePrevious studies have shown that multiple stem cell implantations might assist adults suffering from complete spinal cord injuries (SCI). Now a groundbreaking study released today in STEM CELLS Translational Medicine shows for the first time that children with SCI might benefit, too.

Marcin Majka, Ph.D., and Danuta Jarocha, Ph.D., led the study at Jagiellonian University College of Medicine in Krakow, Poland. “Although it was conducted on a small number of patients carrying a different injury level and type, preliminary results demonstrate the possibility of attaining neurological, motor and sensation and quality-of-life improvement in children with a chronic complete spinal cord injury through multiple bone marrow derived cell (BMNC) implantations. Intravenous implantations of these cells seem to prevent and/or help the healing of pressure ulcers,” Dr. Majka said. Continue Reading »

Optimal site for cell transplantation to treat spinal cord injury investigated

Published: November 21, 2013 | Category: News | Spinal Cord Injury:

After laboratory mice received a contusive spinal cord injury at the T10 level, low and high doses of neural stem/progenitor cells (NS/PCs) derived from fetal bioluminescent-labeled transgenic mice were injected into four groups of mice at either the lesion epicenter or at rostral and caudal sites. A control group was similarly injected with phosphate buffered saline. The mice receiving the NS/PC cells experienced motor functional recovery while those in the control group did not.

It is known that transplanting neural stem/progenitor cells (NS/PCs) into the spinal cord promotes functional recovery after spinal cord injury (SCI). However, which transplantation sites provide optimal benefit? Continue Reading »

Scientists grow new stem cells in a living mouse

Published: September 11, 2013 | Category: News

LONDON (Reuters) – Scientists have succeeded in generating new stem cells in living mice and say their success opens up possibilities for the regeneration of damaged tissue in people with conditions ranging from heart failure to spinal cord injury.

The researchers used the same “recipe” of growth-boosting ingredients normally used for making stem cells in a petri dish, but introduced them instead into living laboratory mice and found they were able to create so-called reprogrammed induced pluripotent stem cells (iPS cells). Continue Reading »

Novel stimulation therapy brings cure for spinal cord injuries closer to reality

Published: August 26, 2013 | Category: News

hospitalWashington, August 26 (ANI): Researchers have discovered a new technique called Biphasic Electrical stimulation (BES), a non-chemical procedure, that they believe can be used for spinal cord injury patients in the future.

Transplantation of Stem Cells is a potential clinical therapy for repair and regeneration of injured spinal cord, and brings new hope for patients. However, the survival rate of transplanted cells is relatively low as the cells are particularly vulnerable to apoptosis in the spinal cord. Continue Reading »

Improvement From Complete to Incomplete Injury Observed in One Patient

Published: February 12, 2013 | Category: News

StemCells, Inc. Announces First Patient Cohort Completes Spinal Cord Injury Trial – Gains in Sensory Function Persist 12 Months After Stem Cell Transplant

NEWARK, Calif., Feb. 12, 2013 (GLOBE NEWSWIRE) — StemCells, Inc. (Nasdaq:STEM) today announced that the twelve-month data from the first patient cohort in the Company’s Phase I/II clinical trial of its proprietary HuCNS-SC® product candidate (purified human neural stem cells) for chronic spinal cord injury continued to demonstrate a favorable safety profile, and showed that the considerable gains in sensory function observed in two of the three patients at the six-month assessment have persisted. Continue Reading »