Articles Tagged: Study
March 8, 2017 | Category: News
Discovery could be key to treating brain and spinal cord injury
A foray into plant biology led one researcher to discover that a natural molecule can repair axons, the thread-like projections that carry electrical signals between cells. Axonal damage is the major culprit underlying disability in conditions such as spinal cord injury and stroke.
Andrew Kaplan, a PhD candidate at the Montreal Neurological Institute and Hospital of McGill University, was looking for a pharmacological approach to axon regeneration, with a focus on 14-3-3, a family of proteins with neuroprotective functions that have been under investigation in the laboratory of Dr. Alyson Fournier, professor of neurology and neurosurgery and senior author on the study. Continue Reading »
February 28, 2017 | Category: News
Patients suffering from complete spinal cord injuries have little to no treatment options that provide meaningful improvement in patient outcomes.
Cambridge, Mass.-based InVivo Therapeutics is trying to change that. Co-founded in 2005 by MIT professor Robert Langer, and surgeon-scientists Joseph Vacanti, M.D., the company has developed a small, bioresorbable and biocompatible device called the Neuro-Spinal Scaffold, to help patients with complete thoracic spinal cord injuries regain some function. Continue Reading »
February 21, 2017 | Category: News
In a Stanford-led research report, three participants with movement impairment controlled an onscreen cursor simply by imagining their own hand movements.
A clinical research publication led by Stanford University investigators has demonstrated that a brain-to-computer hookup can enable people with paralysis to type via direct brain control at the highest speeds and accuracy levels reported to date. Continue Reading »
January 24, 2017 | Category: News
Early clinical trial results announced offer new hope in regenerative medicine
A new therapy to treat spinal cord injuries in people who have lost all motor and sensory function below the injury site shows additional motor function improvement at 6-months and 9-months following treatment with 10 million AST-OPC1. The positive efficacy results from an ongoing research study were announced on Jan. 24 in a conference held by Asterias Biotherapeutics, Inc., the biotechnology company that manufactures AST-OPC1. Continue Reading »
December 13, 2016 | Category: News
UCLA scientists test electrical stimulation that bypasses injury; technique boosts patient’s finger control, grip strength up to 300 percent
A spinal stimulator being tested by doctors at Ronald Reagan UCLA Medical Center is showing promise in restoring hand strength and movement to a California man who broke his neck in a dirt bike accident five years ago.
In June, Brian Gomez, now 28, became one of the first people in the world to undergo surgery for the experimental device. Continue Reading »
December 8, 2016 | Category: News
Researchers have developed a urine test revealing the presence of a neurotoxin that likely worsens the severity and pain of spinal cord injuries, suggesting a new tool to treat the injuries.
The neurotoxin, called acrolein, is produced within the body after nerve cells are damaged, increasing pain and triggering a cascade of biochemical events thought to worsen the injury’s severity. Continue Reading »
December 2, 2016 | Category: News
The gut microbiome undergoes changes after a patient suffers a spinal cord injury, according to a new study.
Researchers from The Ohio State University Wexner Medical Center used mice models of spinal cord injury in order to determine whether gut bacteria dysbiosis – or, functional interruption – affects the recovery of neurological function in patients after a traumatic spinal cord injury. The researchers wrote that this dysbiosis can both cause and exacerbate a number of diseases. The study authors studied changes in the mice’s microbiomes after their injuries for a month to predict the range of their locomotor impairment, they wrote. Continue Reading »
November 16, 2016 | Category: News
WASHINGTON, D.C. (November 16, 2016) — Suzanne Groah, MD, MSPH, has been awarded a $500,000 grant by the Craig H. Neilsen Foundation to support screening for urinary tract infections (UTIs) among patients with spinal cord injuries at MedStar National Rehabilitation Network.
“Urinary tract infection is the most common bacterial infection seen in the outpatient setting and the most common healthcare-associated infection, making it a major worldwide public health problem,” said Dr. Groah. In addition, spinal cord injury patients are at high risk for recurrent UTI, which is known to cause significant pain and discomfort; however, mobility limitations often create barriers to these patients receiving comprehensive care. Continue Reading »
November 2, 2016 | Category: Answers
Researchers have identified a protein in zebrafish that plays a role in helping heal major spinal cord injuries. The results, published in the 4 November issue of Science, could provide an important clue for researchers looking for ways to facilitate similar tissue repair in humans.
While mammals lack the ability to regenerate nervous system tissue after spinal cord injury, zebrafish can regenerate such tissue. The mechanisms behind this recovery have remained elusive.
“Only six to eight weeks after a paralyzing injury that completely severs their spinal cord, zebrafish form new neurons, regrow axons and recover the ability to swim. Importantly, these regenerative events proceed without massive scarring,” explained Mayssa Mokalled of Duke University, a researcher involved in the study. Continue Reading »
October 17, 2016 | Category: News
COLUMBUS, Ohio – The community of bacteria that live in our intestines, also called the “gut microbiome,” is important to normal intestinal function. Knowing that spinal cord injuries often negatively affect the gut’s ability to do its job, researchers at The Ohio State University Wexner Medical Center showed that spinal cord injury causes profound changes in the gut microbiota. They also showed that feeding mice probiotics after a spinal cord injury confers neuroprotection and improves functional recovery.
The findings are published online today in the Journal of Experimental Medicine. Continue Reading »