Articles Tagged: Study
January 24, 2017 | Category: News
Early clinical trial results announced offer new hope in regenerative medicine
A new therapy to treat spinal cord injuries in people who have lost all motor and sensory function below the injury site shows additional motor function improvement at 6-months and 9-months following treatment with 10 million AST-OPC1. The positive efficacy results from an ongoing research study were announced on Jan. 24 in a conference held by Asterias Biotherapeutics, Inc., the biotechnology company that manufactures AST-OPC1. Continue Reading »
December 13, 2016 | Category: News
UCLA scientists test electrical stimulation that bypasses injury; technique boosts patient’s finger control, grip strength up to 300 percent
A spinal stimulator being tested by doctors at Ronald Reagan UCLA Medical Center is showing promise in restoring hand strength and movement to a California man who broke his neck in a dirt bike accident five years ago.
In June, Brian Gomez, now 28, became one of the first people in the world to undergo surgery for the experimental device. Continue Reading »
December 8, 2016 | Category: News
Researchers have developed a urine test revealing the presence of a neurotoxin that likely worsens the severity and pain of spinal cord injuries, suggesting a new tool to treat the injuries.
The neurotoxin, called acrolein, is produced within the body after nerve cells are damaged, increasing pain and triggering a cascade of biochemical events thought to worsen the injury’s severity. Continue Reading »
December 2, 2016 | Category: News
The gut microbiome undergoes changes after a patient suffers a spinal cord injury, according to a new study.
Researchers from The Ohio State University Wexner Medical Center used mice models of spinal cord injury in order to determine whether gut bacteria dysbiosis – or, functional interruption – affects the recovery of neurological function in patients after a traumatic spinal cord injury. The researchers wrote that this dysbiosis can both cause and exacerbate a number of diseases. The study authors studied changes in the mice’s microbiomes after their injuries for a month to predict the range of their locomotor impairment, they wrote. Continue Reading »
November 16, 2016 | Category: News
WASHINGTON, D.C. (November 16, 2016) — Suzanne Groah, MD, MSPH, has been awarded a $500,000 grant by the Craig H. Neilsen Foundation to support screening for urinary tract infections (UTIs) among patients with spinal cord injuries at MedStar National Rehabilitation Network.
“Urinary tract infection is the most common bacterial infection seen in the outpatient setting and the most common healthcare-associated infection, making it a major worldwide public health problem,” said Dr. Groah. In addition, spinal cord injury patients are at high risk for recurrent UTI, which is known to cause significant pain and discomfort; however, mobility limitations often create barriers to these patients receiving comprehensive care. Continue Reading »
November 2, 2016 | Category: Answers
Researchers have identified a protein in zebrafish that plays a role in helping heal major spinal cord injuries. The results, published in the 4 November issue of Science, could provide an important clue for researchers looking for ways to facilitate similar tissue repair in humans.
While mammals lack the ability to regenerate nervous system tissue after spinal cord injury, zebrafish can regenerate such tissue. The mechanisms behind this recovery have remained elusive.
“Only six to eight weeks after a paralyzing injury that completely severs their spinal cord, zebrafish form new neurons, regrow axons and recover the ability to swim. Importantly, these regenerative events proceed without massive scarring,” explained Mayssa Mokalled of Duke University, a researcher involved in the study. Continue Reading »
October 17, 2016 | Category: News
COLUMBUS, Ohio – The community of bacteria that live in our intestines, also called the “gut microbiome,” is important to normal intestinal function. Knowing that spinal cord injuries often negatively affect the gut’s ability to do its job, researchers at The Ohio State University Wexner Medical Center showed that spinal cord injury causes profound changes in the gut microbiota. They also showed that feeding mice probiotics after a spinal cord injury confers neuroprotection and improves functional recovery.
The findings are published online today in the Journal of Experimental Medicine. Continue Reading »
September 14, 2016 | Category: News
An experimental stem cell therapy developed by Asterias Biotherapeutics restored some movement to patients paralyzed by recent spinal cord injuries, according to interim data from a small study being presented on Wednesday.
One of the five patients in the trial regained use of both arms and hands, and is now able to feed himself, send texts on a phone and operate a wheelchair, the Fremont, California-based company said.
Three months after the cells were implanted, the study met its efficacy goal of two patients regaining return of two motor levels of functioning on at least one side of their body, the company said.
All five people in the study have experienced some upper extremity improvement so far, Asterias said. Continue Reading »
September 7, 2016 | Category: News
| Spinal Cord Injury: Quadriplegia
Initial Results Offer Hope for Patients to Reclaim Independence After Suffering Severe Spinal Injury
LOS ANGELES, Sept. 7, 2016 /PRNewswire/ — Keck Medical Center of USC today announced that a team of doctors became the first in California to inject an experimental treatment made from stem cells, AST-OPC1, into the damaged cervical spine of a recently paralyzed 21-year-old man as part of a multi-center clinical trial. Continue Reading »
September 1, 2016 | Category: Answers
| Spinal Cord Injury: C-2
Researches in Germany studied whether time of surgery impacted neurological outcomes for patients with acute spinal cord injury, according to Journal of Therapeutics and Clinical Risk Management.
Specifically, they analyzed 51 spinal cord injury patients, aged an average of 43.4 years. The patients had acute spinal fractures from C2 to L3 or nonosseous lesions. Continue Reading »